I B /I B deficiency reveals that a critical NF- B dosage is required for lymphocyte survival
نویسندگان
چکیده
منابع مشابه
I B I B deficiency reveals that a critical NF- B dosage is required for lymphocyte survival
In most cells, the NFB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the I Bs. Here, we show that combined I B I B deficiency in mice leads to neonatal death, elevated B binding activity, overexpression of NFB target genes, and disruption of lymphocyte production. In I B I B -deficient fetuses, B220 IgM B cells and single-positive T cells die by a...
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Nuclear factor B (NFB) transcription factors are key regulators of immune, inflammatory, and acute-phase responses and are also implicated in the control of cell proliferation and apoptosis. While perturbations in NFB activity impact strongly on Band T-cell development, little is known about the role for NFB in natural killer (NK) cell differentiation. Inhibitors of NFB (I Bs) act to restrain N...
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The regulation of gene expression, which allows a living cell to express a defined set of genes according to its environmental conditions and stage of development, occurs primarily at the level of transcription. The precise temporal and spatial control of the transcription factor NFκB has become a paradigm for the complexity of transcriptional regulation in eukaryotes. IκB, the inhibitor and ce...
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Nuclear factor B (NFB) transcription factors regulate genes responsible for critical cellular processes. I B , , and bind to NFBs and inhibit their transcriptional activity. The NFB-binding domains of I Bs contain six ankyrin repeats (ARs), which adopt a -hairpin/ -helix/loop/ -helix/loop architecture. I B appears compactly folded in the I B NFB crystal structure, but biophysical studies sugges...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2535880100